The Peregrine Falcon was listed as an Endangered Species by the U.S. Fish and Wildlife Service in 1972 following the catastrophic decline of the species worldwide (see threats). In response and after the banning of DDT, the Peregrine Fund, a non-profit organization, was organized with a mission to reintroduce the species into North America. Some of the earliest reintroduction sites included historic nesting areas in Pennsylvania during the 1970s. The Peregrine has subsequently experienced one of the most dramatic recoveries of any endangered species, and was formally removed from the federal list in 1999.

The Peregrine Falcon continues to be listed by the Pennsylvania Game Commission as an Endangered species because of the small local population and continued threats.