Land Recycling Program Toxicity Database

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Toxicity Value Change Summary 

Table of Contents

Introduction

The medium-specific concentrations of Statewide health standard in 25 Pa Code Chapter 250 were derived from the toxicity values listed in Appendix A Table 5 of the Regulations. Toxicity values in that table were based on information available at the time when the final regulation package was submitted for promulgation.  Due to the continuous development of the toxicity values by USEPA, ATSDR and California EPA, some of the current toxicity values from these agencies may be different from the toxicity values listed in the Regulations.  This page provides summary tables regarding these toxicity value changes. [NOTE: Amendments to Chapter 250 are effective as of November 24, 2001. Effective Statewide Health Standard MSCs can be found at: http://www.depweb.state.pa.us/ocrlgs/cwp/view.asp?a=1459&Q=518871&ocrlgsNav=|38248|38262|]

The information on this page is intended as a compilation of updated data from sources specified in Chapter 250.605, relating to Sources of Toxicity Information. It is provided here for informational purposes and for the convenience in establishing Site-specific standards. These changes will be incorporated into a future amendment to Appendix A to Chapter 250, as data used to calculate medium-specific concentrations under the Statewide health standard.

 

RfDo Change Summary

CAS_NUMBER CHEMICAL NAME RfDo in Chapter 250, Appendix A, Table 5 (mg/kg/day) RfDo in This Database (mg/kg/day) Data Source

000067-64-1

ACETONE

1.E-01

9.E-01

I

000107-02-8

ACROLEIN

2.E-02

5.E-04

I

007440-39-3

BARIUM AND COMPOUNDS

7.E-02

2.E-01

I

000071-43-2

BENZENE

3.E-03

4.E-03

I

000100-44-7

BENZYL CHLORIDE

 

2.E-03

P

007440-42-8

BORON AND COMPOUNDS

9.E-02

2.E-01

I

000100-00-5

CHLORONITROBENZENE, P-

 

1.E-03

P

000072-54-8

DDD, 4,4'-

 

2.E-03

P

000132-64-9

DIBENZOFURAN

 

1.E-03

P

000106-93-4

DIBROMOETHANE, 1,2- (ETHYLENE DIBROMIDE)

5.71.E-05

9.E-03

I

000541-73-1

DICHLOROBENZENE, 1,3-

3.E-02

3.E-03

N

000075-34-3

DICHLOROETHANE, 1,1-

1.E-01

2.E-01

P

000107-06-2

DICHLOROETHANE, 1,2-

3.E-02

2.E-02

P

000075-35-4

DICHLOROETHYLENE, 1,1-

9.E-03

5.E-02

I

000534-52-1

DINITRO-O-CRESOL, 4,6-

 

1.E-04

P

000123-91-1

DIOXANE, 1,4-

 

1.E-01

D

000591-78-6

HEXANONE, 2- (METHYL N-BUTYL KETONE)

 

4.E-02

N

000143-50-0

KEPONE

5.E-04

2.E-04

P

007439-93-2

LITHIUM

 

2.E-02

N

007439-96-5

MANGANESE

1.4E-01

4.7E-02

I (for Soil and Water Exposures)

000094-74-6

METHYLCHLOROPHENOXYACETIC ACID (MCPA)

 

5.E-04

I

000091-57-6

METHYLNAPHTHALENE, 2-

2.E-02

4.E-03

I

000099-09-2

NITROANILINE, M-

5.7E-05

3.E-04

P

000088-74-4

NITROANILINE, O-

5.7E-05

3.E-03

P

000100-01-6

NITROANILINE, P-

5.7E-05

3.E-03

P

000062-75-9

NITROSODIMETHYLAMINE, N-

 

8.E-06

P

000086-30-6

NITROSODIPHENYLAMINE, N-

 

2.E-02

P

007790-98-9

PERCHLORATE

 

7.E-04

I

000108-95-2

PHENOL

6.E-01

3.E-01

I

000108-98-5

PHENYL MERCAPTAN

 

1.E-05

H

000108-46-3

RESORCINOL

 

2.E+00

ITER Peer Review Value

000109-99-9

TETRAHYDROFURAN

 

2.E-01

N

000108-88-3

TOLUENE

2.E-01

8.E-02

I

000071-55-6

TRICHLOROETHANE, 1,1,1-

2.8E-01

2.E+00

I

000088-06-2

TRICHLOROPHENOL, 2,4,6-

3.E-04

1.E-03

P

000055-63-0

TRINITROGLYCEROL (NITROGLYCERIN)

 

1.E-04

P

001330-20-7

XYLENES (TOTAL)

2.E+00

2.E-01

I

 

  RfDi Change Summary

CAS_NUMBER CHEMICAL NAME RfDi  in Chapter 250, Appendix A, Table 5 (mg/kg/day) RfDi in This Database (mg/kg/day) Data Source

000071-43-2

BENZENE

1.7E-03

8.6E-03

I

000100-44-7

BENZYL CHLORIDE

 

2.E-03

Route-to-route extrapolation from RfDo

000106-99-0

BUTADIENE, 1,3-

 

5.7E-04

I

000056-23-5

CARBON TETRACHLORIDE

5.71E-04

5.E-02

D

000108-90-7

CHLOROBENZENE

5.71E-03

5.E-03

H

000067-66-3

CHLOROFORM

9.E-05

1.4E-02

N

000100-00-5

CHLORONITROBENZENE, P-

 

1.7E-04

P

007440-48-4

COBALT

5.0E-06

5.7E-06

P

000110-82-7

CYCLOHEXANE

 

1.7E+00

I

000072-54-8

DDD, 4,4'-

 

2.E-03

Route-to-route extrapolation from RfDo

000132-64-9

DIBENZOFURAN

 

1.E-03

Route-to-route extrapolation from RfDo

000106-93-4

DIBROMOETHANE, 1,2- (ETHYLENE DIBROMIDE)

5.71E-05

2.6E-03

I

000095-50-1

DICHLOROBENZENE, 1,2-

5.71E-02

4.E-02

H

000075-71-8

DICHLORODIFLUOROMETHANE (FREON 12)

5.71E-02

5.E-02

H

000075-34-3

DICHLOROETHANE, 1,1-

1.43E-01

1.E-01

H

000107-06-2

DICHLOROETHANE, 1,2-

2.3E-01

7.E-01

D

000075-35-4

DICHLOROETHYLENE, 1,1-

9.E-03

5.7E-02

I

000156-60-5

DICHLOROETHYLENE, TRANS-1,2-

2.E-02

1.7E-02

P

000075-09-2

DICHLOROMETHANE (METHYLENE CHLORIDE)

8.57E-01

3.E-01

D

000534-52-1

DINITRO-O-CRESOL, 4,6-

 

1.E-04

Route-to-route extrapolation from RfDo

000123-91-1

DIOXANE, 1,4-

 

1.E+00

D

000050-00-0

FORMALDEHYDE

1.1E-03

2.8E-03

D

000064-18-6

FORMIC ACID

2E+00

8.6E-04

N

000110-54-3

HEXANE

5.71E-02

2.E-01

I

000591-78-6

HEXANONE, 2- (METHYL N-BUTYL KETONE)

 

1.4E-03

N

000143-50-0

KEPONE

 

2.E-04

Route-to-route extrapolation from RfDo

007439-93-2

LITHIUM

 

2.E-02

Route-to-route extrapolation from RfDo

000074-87-3

METHYL CHLORIDE

2.9E-02

3.E-02

I

000078-93-3

METHYL ETHYL KETONE

2.9E-01

1.4E+00

I

000108-10-1

METHYL ISOBUTYL KETONE

2.3E-02

8.6E-01

I

025013-15-4

METHYL STYRENE (MIXED ISOMERS)

1.1E-02

1.E-02

H

000094-74-6

METHYLCHLOROPHENOXYACETIC ACID (MCPA)

 

5.E-04

Route-to-route extrapolation from RfDo

000091-57-6

METHYLNAPHTHALENE, 2-

8.6E-04

4.E-03

Route-to-route extrapolation from RfDo

007440-02-0

NICKEL

5.7E-05

2.6E-05

D

000099-09-2

NITROANILINE, M-

5.7E-05

3.E-04

P

000100-01-6

NITROANILINE, P-

5.7E-05

1.E-03

P

000062-75-9

NITROSODIMETHYLAMINE, N-

 

8.E-06

Route-to-route extrapolation from RfDo

000086-30-6

NITROSODIPHENYLAMINE, N-

 

2.E-02

Route-to-route extrapolation from RfDo

007790-98-9

PERCHLORATE

 

7.E-04

Route-to-route extrapolation from RfDo

000108-95-2

PHENOL

6.0E-01

3.E-01

Route-to-route extrapolation from RfDo

000108-98-5

PHENYL MERCAPTAN

 

1.E-05

Route-to-route extrapolation from RfDo

000109-99-9

TETRAHYDROFURAN

 

8.6E-02

N

000108-88-3

TOLUENE

1.14E-01

1.4E+00

I

000071-55-6

TRICHLOROETHANE, 1,1,1-

6.3E-01

1.4E+00

I

000088-06-2

TRICHLOROPHENOL, 2,4,6-

3.E-04

1.E-03

Route-to-route extrapolation from RfDo

000096-19-5

TRICHLOROPROPENE, 1,2,3-

 

3.E-04

P

000121-44-8

TRIETHYLAMINE

 

2.E-03

I

000095-63-6

TRIMETHYLBENZENE, 1,3,4- (TRIMETHYLBENZENE, 1,2,4-)

1.7E-03

2.E-03

P

000055-63-0

TRINITROGLYCEROL (NITROGLYCERIN)

 

1.E-04

Route-to-route extrapolation from RfDo

001330-20-7

XYLENES (TOTAL)

1.20E-01

2.9E-02

I

 

  CSFo Change Summary

CAS_NUMBER CHEMICAL NAME CSFo in Chapter 250, Appendix A, Table 5 [(mg/kg/day)-1] CSFo in This Database [(mg/kg/day)-1] Data Source

000071-43-2

BENZENE

 2.9E-02

5.5E-02

I

000057-57-8

BETA PROPIOLACTONE

  

1.4E+01

C

000085-68-7

BUTYLBENZYL PHTHALATE

  

1.9E-03

P

000106-47-8

CHLOROANILINE, P-

  

5.4E-02

P

000067-66-3

CHLOROFORM

6.1E-03

  

I [A dose of 0.01 mg/kg/day (equal to the RfD) can be considered protective against cancer risk.]

018540-29-9

CHROMIUM (VI)

1.9E-01

 

 

Withdrawn by California EPA

000106-93-4

DIBROMOETHANE, 1,2- (ETHYLENE DIBROMIDE)

 8.5E+01

2.E+00

I

000075-35-4

DICHLOROETHYLENE, 1,1-

6.E-01

 

 

Withdrawn from IRIS

000123-31-9

HYDROQUINONE

  

5.6E-02

P

000143-50-0

KEPONE

 1.6E+01

8.E+00

P

000099-09-2

NITROANILINE, M-

  

2.E-02

P

000100-01-6

NITROANILINE, P-

  

2.E-02

P

012674-11-2

PCB-1016 (AROCLOR)

 9.E-02

7.E-02

I

011104-28-2

PCB-1221 (AROCLOR)

 5.E-01

2.E+00

I

011141-16-5

PCB-1232 (AROCLOR)

 5.E-01

2.E+00

I

053469-21-9

PCB-1242 (AROCLOR)

 5.E-01

2.E+00

I

012672-29-6

PCB-1248 (AROCLOR)

 1.8.E+00

2.E+00

I

011097-69-1

PCB-1254 (AROCLOR)

 1.8.E+00

2.E+00

I

011096-82-5

PCB-1260 (AROCLOR)

 6.E-01

2.E+00

I

000076-01-7

PENTACHLOROETHANE

  

9.E-02

P

000091-22-5

QUINOLINE

 1.2E+01

3.E+00

I

000109-99-9

TETRAHYDROFURAN

  

7.6E-03

N

000055-63-0

TRINITROGLYCEROL (NITROGLYCERIN)

  

1.7E-02

P

 

   CSFi Change Summary

 

CAS_NUMBER CHEMICAL NAME CSFi  in Chapter 250, Appendix A, Table 5 [(mg/kg/day)-1] CSFi in This Database [(mg/kg/day)-1] Data Source

000057-57-8

BETA PROPIOLACTONE

 

1.4E+1

C

000106-99-0

BUTADIENE, 1,3-

9.8E-01 

1.1E-1

I

000085-68-7

BUTYLBENZYL PHTHALATE

 

1.9E-3

Route-to-route extrapolation from CSFo

000106-47-8

CHLOROANILINE, P-

 

5.4E-2

Route-to-route extrapolation from CSFo

000100-00-5

CHLORONITROBENZENE, P-

 

1.8E-02

Route-to-route extrapolation from CSFo

007440-48-4

COBALT

 

9.8E+00

P

000106-93-4

DIBROMOETHANE, 1,2- (ETHYLENE DIBROMIDE)

7.7E-01 

2.1E+00

I

000075-34-3

DICHLOROETHANE, 1,1-

5.6E-03 

5.7E-03

C

000075-35-4

DICHLOROETHYLENE, 1,1-

1.75E-01 

 

Withdrawn from IRIS

000123-31-9

HYDROQUINONE

 

5.6E-02

Route-to-route extrapolation from CSFo

000143-50-0

KEPONE

1.61E+01 

8.E-00

Route-to-route extrapolation from CSFo

000066-27-3

METHYL METHANESULFONATE

9.8E-02 

9.9E-02

C

001634-04-4

METHYL TERTIARY BUTYL ETHER (MTBE)

1.8E-03 

9.1E-04

C

000099-09-2

NITROANILINE, M-

 

2.E-02

Route-to-route extrapolation from CSFo

000100-01-6

NITROANILINE, P-

 

2.E-02

Route-to-route extrapolation from CSFo

000086-30-6

NITROSODIPHENYLAMINE, N-

9.1E-03 

9.E-03

C

012674-11-2

PCB-1016 (AROCLOR)

9.E-02 

7.E-02

I

011104-28-2

PCB-1221 (AROCLOR)

5.E-01 

2.E+00

I

011141-16-5

PCB-1232 (AROCLOR)

5.E-01 

2.E+00

I

053469-21-9

PCB-1242 (AROCLOR)

5.E-01 

2.E+00

I

012672-29-6

PCB-1248 (AROCLOR)

1.8E+00 

2.E+00

I

011097-69-1

PCB-1254 (AROCLOR)

1.8E+00

2.E+00

I

011096-82-5

PCB-1260 (AROCLOR)

6.E-01

2.E+00

I

000076-01-7

PENTACHLOROETHANE

 

9.E-02

Route-to-route extrapolation from CSFo

000109-99-9

TETRAHYDROFURAN

 

6.8E-03

N

000055-63-0

TRINITROGLYCEROL (NITROGLYCERIN)

 

1.7E-02

Route-to-route extrapolation from CSFo

 

Data Sources of Toxicity Values:

C = California EPA, Cancer Potency Factor

D = ATSDR Minimal Risk Level (MRL)

H = Health Effect Assessment Summary Table (HEAST)

I = Integrated Risk Information System (IRIS)

M = EPA Drinking Water Regulations and Health Advisories

N = EPA NCEA Provisional Value

P = EPA Provisional Peer Reviewed Toxicity Value

 

logo of mailPlease forward comments and suggestions regarding this web page or the database to:
Samuel Fang at sfang@state.pa.us.

 

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Last Modified on February 4, 2008 12:11:23 PM